Scientific and political problems for controversial dairy hormone
A scientific and political
noose appears to be tightening around
Monsanto corporation's controversial hormone product, rBGH, also called rBST. For the past 18 months, Monsanto has been
aggressively marketing its genetically-engineered hormone to
farmers here and abroad, to increase the milk yield of dairy
cows. Cows injected with rBGH every two weeks produce 10 to 20 percent
more milk than untreated cows. The U.S. Food and Drug
Administration (FDA) in late 1993 declared the milk from
rBGH-treated cows safe. However, new scientific studies
published this summer suggest that milk from rBGH-treated cows
may not be as safe for humans as was previously believed.
Political troubles for rBGH are mounting as well. Because of unresolved scientific issues related to the safety of milk from rBGH-treated cows, the international standards-setting organization in Rome, Italy -- Codex Alimentarius -- earlier this summer rejected a U.S. proposal to declare the use of rBGH safe, posing no significant health risk. In the debate at the Codex meeting, the U.S. government promoted rBGH, but the 14-nation European Union successfully opposed approval, winning by a vote of 34 to 31. Other European countries besides the EU have placed a moratorium on use of rBGH, as has Canada. In June, the Canadian House Committee on Health, an all-party Parliamentary committee, unanimously called for a minimum 2-year moratorium on rBGH to examine the unresolved human health issues. The Agriculture Committee called for a similar moratorium but not limited to two years and limited to human health issues. Monsanto is aggressively working to have such moratoriums lifted, but the newly-published scientific information seems certain to make Monsanto's task increasingly difficult.
Meanwhile back in the U.S., consumer advocacy groups (Food & Water, Inc., in Marshfield, Vermont [phone: 1-800-EAT-SAFE], and the Pure Food Campaign in Little Marais, Minnesota [phone: 1-800-451-7670]) are locked in pitched battles with rBGH-using dairies. Pure Food is using more of a scattergun approach, while Food & Water has take sharp aim at two major dairy conglomerates -- Land O' Lakes and Cabot Creamery. Both campaigns aim to force dairies to stop using rBGH. The consumer groups seem likely to get the upper hand here, as the main arguments being used by the dairy corporations are undercut by the new scientific findings.
Concerns raised about IGF-1 before the hormone was approved
When a cow
is injected with rBGH, its milk production is
stimulated, but not directly. The presence of rBGH in the cow's
blood stimulates production of another hormone, called
Insulin-Like Growth Factor 1, or IGF-1 for short. It is IGF-1
that stimulates milk production.
IGF-1 is a naturally-occurring hormone-protein in both cows and humans. The IGF-1 in cows is chemically identical to the IGF-1 in humans. The use of rBGH increases the levels of IGF-1 in the cow's milk, though the amount of the increase is disputed. Furthermore, IGF-1 in milk is not destroyed by pasteurization. Because IGF-1 is active in humans -- causing cells to divide -- any increase in IGF-1 in milk raises obvious questions: will it cause inappropriate cell division and growth, causing tumors?
According to last year's Statistical Abstract of the U.S., Americans in 1992 each consumed an average of 564.6 pounds of cows' milk and milk products, or about 1.54 pounds per person per day; this includes milk, cream, ice cream, ice milk, buttermilk, cheese, cottage cheese, various "dips," and yogurt. Because milk is consumed in such large quantities, an increase in a growth-promoting hormone in milk is of potentially great public health interest.
When the National Institutes of Health (NIH) reviewed the safety of rBGH back in 1991 (concluding that it was safe), they acknowledged their ignorance about IGF-1: "Whether the additional amount of insulin-like growth factor 1 in milk from [rBGH-treated cows] has a local effect on the esophagus, stomach or intestines is unknown." One of the NIH's six recommendations for further research was, "Determine the acute and chronic actions of IGF-1, if any, in the upper gastrointestinal tract."
The Council on Scientific Affairs of the American Medical Association formally expressed concern about IGF-1 related to rBGH in 1991, saying, "Further studies will be required to determine whether ingestion of higher than normal concentrations of bovine insulin-like growth factor [IGF-1] is safe for children, adolescents, and adults."
The position of Monsanto, and of the dairy conglomerates using rBGH, are different. Monsanto's public position since 1994 has been that IGF-1 is not elevated in the milk from rBGH-treated cows. For example, writing in the British journal, Lancet, in 1994, Monsanto researchers said "...IGF-1 concentration in milk of rBST-treated cows is unchanged," and "...there is no evidence that hormonal content of milk from rBST-treated cows is in any way different from cows not so treated." However, in a published letter, the British researcher T. B. Mepham reminded Monsanto that in its 1993 application to the British government for permission to sell rBGH in England, Monsanto itself reported that "the IGF-1 level went up substantially [about five times as much]." The U.S. FDA acknowledges that IGF-1 is elevated in milk from rBGH-treated cows. Other proponents of rBGH acknowledge that it at least doubles the amount of IGF-1 hormone in the milk. The earliest report in the literature found that IGF-1 was elevated in the milk of rBGH-treated cows by a factor of 3.6. No one besides Monsanto seems to argue that rBGH treatment of cows has no effect on IGF-1 levels in their milk.
The dairy conglomerates -- Land O' Lakes and Cabot Creamery -- acknowledge that IGF-1 is elevated in their milk. However, they argue that it doesn't matter. They point out (correctly) that human saliva has IGF-1 in it, and they argue that that doesn't matter either because IGF-1 is broken down during digestion.
New research raises questions about IGF-1 and tumors
A new study
published in August shows this to be wrong. IGF-1
by itself in saliva is destroyed by digestion, but IGF-1 in the
presence of casein (the principal protein in cows' milk) is not
destroyed by the digestive system. Casein has a protective
effect on IGF-1, so IGF-1 in cows milk remains intact in the gut
of humans who drink rBGH-treated milk. There was reason to
believe that this might be true because researchers in 1984 had
shown that another growth hormone, Epidermal Growth Factor (EGF),
in the presence of casein was not degraded by the digestive
system. However, proof had been lacking for IGF-1 until now.
So the saliva argument has been invalidated by scientific experiment. The question then becomes, what are the likely effects of IGF-1 in contact with cells of the human gastrointestinal tract? This is the question the NIH said needed answering back in 1991. Now there are at least three relevant studies.
Taken together, these new studies all point to the need to understand more about rBGH and its effects on IGF-1 levels in cows' milk, and an additional need to understand what happens to the human gastrointestinal tract when it comes in contact with enhanced levels of IGF-1. The relationship of IGF-1 to cancer deserves special attention. Even researchers who are known as proponents of rBGH have recently said in print, "Many more potential effects of ingested IGF-1 on the gastrointestinal tract and the local immune system of the gut need to be explored."
In the face of this growing body of scientific evidence, how long can rBGH-using dairy corporations maintain that their milk, butter and cheese are wholesome and safe beyond doubt?
[Editor's note: This commentary originally appeared Rachel's Environment and Health Weekly, published by the Environmental Research Foundation. Monitor Publishing is currently working with the Foundation to make its entire archive of more than 450 reports available in a searchable database.]
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